Department Publications 2008

Akk, G., P. Li, J. Bracamontes, D. E. Reichert, D. F. Covey and J. H. Steinbach (2008). "Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids." Mol Pharmacol 74(3): 614-27.

Akk, G., S. Mennerick and J. H. Steinbach (2008). "Actions of anesthetics on excitatory transmitter-gated channels." Handb Exp Pharmacol(182): 53-84.

Alter, B. J. and R. W. t. Gereau (2008). "Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity." Neuron 57(5): 629-31.

Avidan, M. S., L. Zhang, B. A. Burnside, K. J. Finkel, A. C. Searleman, J. A. Selvidge, L. Saager, M. S. Turner, S. Rao, M. Bottros, C. Hantler, E. Jacobsohn and A. S. Evers (2008). "Anesthesia awareness and the bispectral index." N Engl J Med 358(11): 1097-108.

Boulet, J. R., D. Murray, J. Kras and J. Woodhouse (2008). "Setting performance standards for mannequin-based acute-care scenarios: an examinee-centered approach." Simul Healthc 3(2): 72-81.

Boyle, W. A. and M. Leone (2008). "Vasopressin in septic shock." N Engl J Med 358(25): 2736; author reply 2737-8.

Bracamontes, J. R. and J. H. Steinbach (2008). "Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors." J Biol Chem 283(38): 26128-36.

Carrasquillo, Y. and R. W. t. Gereau (2008). "Hemispheric lateralization of a molecular signal for pain modulation in the amygdala." Mol Pain 4: 24.

Cattano, D., A. Vannucci, A. Nicolini, C. Nania, S. Buzzigoli and C. Eby (2008). "Varicella fulminant hepatitis in an adult patient with Factor V Leiden mutation and trisomy 8 related myelodysplastic syndrome." J Clin Virol 43(1): 134-5.

Cattano, D., P. Williamson, K. Fukui, M. Avidan, A. S. Evers, J. W. Olney and C. Young (2008). "Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain." Can J Anaesth 55(7): 429-36.

Clark, J. A., A. T. Clark, R. S. Hotchkiss, T. G. Buchman and C. M. Coopersmith (2008). "Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis." Shock 30(1): 36-42.

Coles, R. and E. D. Kharasch (2008). "Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes." Pharm Res 25(6): 1405-11.

Crowder, C. M. (2008). "Does natural selection explain the universal response of metazoans to volatile anesthetics?" Anesth Analg 107(3): 862-3.

Cruz-Orengo, L., A. Dhaka, R. J. Heuermann, T. J. Young, M. C. Montana, E. J. Cavanaugh, D. Kim and G. M. Story (2008). "Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1." Mol Pain 4: 30.

Dalal, P. G., D. Murray, A. Feng, D. Molter and J. McAllister (2008). "Upper airway dimensions in children using rigid video-bronchoscopy and a computer software: description of a measurement technique." Paediatr Anaesth 18(7): 645-53.

Ekins, S., M. Iyer, M. D. Krasowski and E. D. Kharasch (2008). "Molecular characterization of CYP2B6 substrates." Curr Drug Metab 9(5): 363-73.

Freeman, B. D., C. Kennedy, T. E. Robertson, C. M. Coopersmith, M. Schallom, C. Sona, L. Cracchiolo, D. J. Schuerer, W. A. Boyle and T. G. Buchman (2008). "Tracheostomy protocol: experience with development and potential utility." Crit Care Med 36(6): 1742-8.

Grundling, M., C. Lehmann, D. Saeger, S. Bohnenstengel, D. Pavlovic, V. Bac, T. Usichenko, K. Meissner, M. Wendt, O. Hung, M. Murphy, S. Whynot and U. Lindequist (2008). "Response of the rat intestinal microcirculation to experimental endotoxemia is attenuated by ampicillin but not by its derivative KKP723." Clin Hemorheol Microcirc 38(3): 163-70.

Guillory, R. K. and O. L. Gunter (2008). "Ultrasound in the surgical intensive care unit." Curr Opin Crit Care 14(4): 415-22.

Hodges, M. R., G. J. Tattersall, M. B. Harris, S. D. McEvoy, D. N. Richerson, E. S. Deneris, R. L. Johnson, Z. F. Chen and G. B. Richerson (2008). "Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons." J Neurosci 28(10): 2495-505.

Holzmann-Pazgal, G., D. Hopkins-Broyles, A. Recktenwald, M. Hohrein, P. Kieffer, C. Huddleston, S. Anshuman and V. Fraser (2008). "Case-control study of pediatric cardiothoracic surgical site infections." Infect Control Hosp Epidemiol 29(1): 76-9.

Hupfl, M., I. Schmatzer, A. Buzath, H. Burger, K. Horauf, G. Ihra, P. Marhofer and P. Nagele (2008). "The effects of aminophylline on bispectral index during inhalational and total intravenous anaesthesia." Anaesthesia 63(6): 583-7.

Jacquin, M. F., J. J. Arends, C. Xiang, L. A. Shapiro, C. E. Ribak and Z. F. Chen (2008). "In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning." J Neurosci 28(14): 3577-85.

Jia, B. and C. M. Crowder (2008). "Volatile anesthetic preconditioning present in the invertebrate Caenorhabditis elegans." Anesthesiology 108(3): 426-33.

Katona, B. W., K. Krishnan, Z. Y. Cai, B. D. Manion, A. Benz, A. Taylor, A. S. Evers, C. F. Zorumski, S. Mennerick and D. F. Covey (2008). "Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens." Eur J Med Chem 43(1): 107-13.

Kertai, M. D. (2008). "Preoperative coronary revascularization in high-risk patients undergoing vascular surgery: a core review." Anesth Analg 106(3): 751-8.

Kertai, M. D., C. M. Westerhout, K. S. Varga, G. Acsady and J. Gal (2008). "Dihydropiridine calcium-channel blockers and perioperative mortality in aortic aneurysm surgery." Br J Anaesth 101(4): 458-65.

Kharasch, E. D. (2008). "Adverse drug reactions with halogenated anesthetics." Clin Pharmacol Ther 84(1): 158-62. Kharasch, E. D. (2008). "Mutations in a molecule: the virtues of antagonism." Mayo Clin Proc 83(10): 1083-6.

Kharasch, E. D., P. S. Bedynek, S. Park, D. Whittington, A. Walker and C. Hoffer (2008). "Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance." Clin Pharmacol Ther 84(4): 497-505.

Kharasch, E. D., P. S. Bedynek, A. Walker, D. Whittington and C. Hoffer (2008). "Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities." Clin Pharmacol Ther 84(4): 506-12.

Kharasch, E. D., D. Mitchell and R. Coles (2008). "Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity." J Clin Pharmacol 48(4): 464-74.

Kharasch, E. D., D. Mitchell, R. Coles and R. Blanco (2008). "Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir." Antimicrob Agents Chemother 52(5): 1663-9.

Kiekkas, P., K. S. Filos, M. Karanikolas, D. Aretha and G. I. Baltopoulos (2008). "Relationships between fever and outcome in intensive care unit patients." Crit Care Med 36(11): 3127-8.

Lehmann, C., R. Scheibe, M. Schade, K. Meissner, M. Grundling, T. Usichenko, M. Wendt, O. Hung, S. Whynot, M. Murphy and D. Pavlovic (2008). "Effects of activated protein C on the mesenteric microcirculation and cytokine release during experimental endotoxemia." Can J Anaesth 55(3): 155-62.

Levy, J. H. and G. J. Despotis (2008). "Transfusion and hemostasis in cardiac surgery." Transfusion 48(1 Suppl): 1S.

Li, P. and G. Akk (2008). "The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor." Br J Pharmacol 155(5): 783-94.

Li, P., D. E. Reichert, A. D. Rodriguez, B. D. Manion, A. S. Evers, V. A. Eterovic, J. H. Steinbach and G. Akk (2008). "Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate." Br J Pharmacol 153(3): 598-608.

Lingle, C. J. (2008). "Mg2+-dependent regulation of BK channels: importance of electrostatics." J Gen Physiol 131(1): 5-11.

Luhmann, S. J., M. Schootman, P. L. Schoenecker, J. E. Gordon and C. Schrock (2008). "Use of femoral nerve blocks in adolescents undergoing patellar realignment surgery." Am J Orthop 37(1): 39-43.

McDunn, J. E., J. T. Muenzer, L. Rachdi, K. C. Chang, C. G. Davis, W. M. Dunne, D. Piwnica-Worms, E. Bernal-Mizrachi and R. S. Hotchkiss (2008). "Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis." Faseb J 22(2): 561-8.

Meissner, K., T. Iber, J. P. Roesner, C. Mutz, H. E. Wagner, C. Layher, U. Bartels, M. Grundling, T. I. Usichenko, M. Wendt, C. Lehmann and D. Pavlovic (2008). "Successful transtracheal lung ventilation using a manual respiration valve: an in vitro and in vivo study." Anesthesiology 109(2): 251-9.

Militante, J., B. W. Ma, G. Akk and J. H. Steinbach (2008). "Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies." Mol Pharmacol 74(3): 764-76.

Nagele, P., B. Zeugswetter, C. Wiener, H. Burger, M. Hupfl, M. Mittlbock and M. Fodinger (2008). "Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia." Anesthesiology 109(1): 36-43.

Okubadejo, G. O., M. R. Talcott, R. E. Schmidt, A. Sharma, A. A. Patel, R. B. Mackey, A. H. Guarino, C. J. Moran and K. D. Riew (2008). "Perils of intravascular methylprednisolone injection into the vertebral artery. An animal study." J Bone Joint Surg Am 90(9): 1932-8.

Peck-Palmer, O. M., J. Unsinger, K. C. Chang, C. G. Davis, J. E. McDunn and R. S. Hotchkiss (2008). "Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival." J Leukoc Biol 83(4): 1009-18.

Peterson, L. R., P. F. Soto, P. Herrero, B. S. Mohammed, M. S. Avidan, K. B. Schechtman, C. Dence and R. J. Gropler (2008). "Impact of gender on the myocardial metabolic response to obesity." JACC Cardiovasc Imaging 1(4): 424-33.

Pezet, M., M. P. Jacob, B. Escoubet, D. Gheduzzi, E. Tillet, P. Perret, P. Huber, D. Quaglino, R. Vranckx, D. Y. Li, B. Starcher, W. A. Boyle, R. P. Mecham and G. Faury (2008). "Elastin haploinsufficiency induces alternative aging processes in the aorta." Rejuvenation Res 11(1): 97-112.

Puyo, C. A., S. M. Tricomi and T. E. Dahms (2008). "Early biochemical markers of inflammation in a swine model of endotracheal intubation." Anesthesiology 109(1): 88-94.

Rajan, S., D. Vyas, A. T. Clark, C. A. Woolsey, J. A. Clark, R. S. Hotchkiss, T. G. Buchman and C. M. Coopersmith (2008). "Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis." Shock 29(4): 483-9.

Robertson, C. M., E. E. Perrone, K. W. McConnell, W. M. Dunne, B. Boody, T. Brahmbhatt, M. J. Diacovo, N. Van Rooijen, L. A. Hogue, C. L. Cannon, T. G. Buchman, R. S. Hotchkiss and C. M. Coopersmith (2008). "Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance." J Surg Res 150(2): 278-85.

Samokhvalov, V., B. A. Scott and C. M. Crowder (2008). "Autophagy protects against hypoxic injury in C. elegans." Autophagy 4(8): 1034-41.

Scaglione, J. B., I. Jastrzebska, K. Krishnan, P. Li, G. Akk, B. D. Manion, A. Benz, A. Taylor, N. P. Rath, A. S. Evers, C. F. Zorumski, S. Mennerick and D. F. Covey (2008). "Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopentaphenanthrenes and cyclopentaanthracenes." J Med Chem 51(5): 1309-18.

Schwulst, S. J., J. T. Muenzer, K. C. Chang, T. S. Brahmbhatt, C. M. Coopersmith and R. S. Hotchkiss (2008). "Lymphocyte phenotyping to distinguish septic from nonseptic critical illness." J Am Coll Surg 206(2): 335-42.

Schwulst, S. J., J. T. Muenzer, O. M. Peck-Palmer, K. C. Chang, C. G. Davis, J. S. McDonough, D. F. Osborne, A. H. Walton, J. Unsinger, J. E. McDunn and R. S. Hotchkiss (2008). "Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis." Shock 30(2): 127-34.

Steinbach, J. H. (2008). "Pharmacology: Unready for action." Nature 454(7205): 704-5. Sun, Y. G., Y. J. Gao, Z. Q. Zhao, B. Huang, J. Yin, G. A. Taylor and Z. F. Chen (2008). "Involvement of P311 in the affective, but not in the sensory component of pain." Mol Pain 4: 23.

Sun, Y. M., M. Cooper, S. Finch, H. H. Lin, Z. F. Chen, B. P. Williams and N. J. Buckley (2008). "Rest-mediated regulation of extracellular matrix is crucial for neural development." PLoS One 3(11): e3656.

Szekely, A., E. Sapi, T. Breuer, M. D. Kertai, G. Bodor, P. Vargha and A. Szatmari (2008). "Aprotinin and renal dysfunction after pediatric cardiac surgery." Paediatr Anaesth 18(2): 151-9.

Tempelhoff, R. (2008). "An optic nerve at risk and a prolonged surgery in the prone position: time to reconsider?" Anesthesiology 108(5): 775-6.

Tempelhoff, R. and J. Yoder (2008). "Monitoring the brain: lack of tools or lack of will?" Crit Care Med 36(6): 1983-4.

Totah, R. A., P. Sheffels, T. Roberts, D. Whittington, K. Thummel and E. D. Kharasch (2008). "Role of CYP2B6 in stereoselective human methadone metabolism." Anesthesiology 108(3): 363-74.

Ulrich, H., G. Akk, A. A. Nery, C. A. Trujillo, A. D. Rodriguez and V. A. Eterovic (2008). "Mode of cembranoid action on embryonic muscle acetylcholine receptor." J Neurosci Res 86(1): 93-107.

Velissaris, D., M. Karanikolas, A. Kalogeropoulos, E. Solomou, P. Polychronopoulos, K. Thomopoulos and C. Labropoulou-Karatza (2008). "Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy." World J Gastroenterol 14(26): 4190-5.

Zeng, X., X. M. Xia and C. J. Lingle (2008). "Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits." J Gen Physiol 132(1): 115-29.