Peter Nagele, MD
Assistant Professor of Anesthesiology
The focus of Dr. Nagele’s research is on perioperative pharmacogenomics. We are interested in how the genetic background influences how patients respond to drugs and how it affects perioperative outcomes. Specifically, we study nitrous oxide (laughing gas) and genetic variation in the folate cycle and homocysteine pathway and how they relate to perioperative myocardial infarction. We also investigate how genetic variation in the adrenergic signaling pathway and the cytochrome P450 enzyme influence the efficacy and safety of beta-blocker treatment.
A second focus of Dr. Nagele’s research is hidradenitis suppurativa. Hidradenitis is a common, chronic skin disease where patients develop recurrent abscesses. It appears that hidradenitis runs in families and may be inherited. In a multidisciplinary team, we try to identify the genetic cause for hidradenitis.
Dr. Nagele’s research support includes grants from the National Institutes of Health (NIH), the American Heart Association (AHA), and the Foundation for Anesthesia Education and Research (FAER).