As a leading research institute, Washington University School of Medicine provides many opportunities for participation in clinical and basic research. Faculty members have extensive experience in clinical research related to cardiothoracic surgery and critical care. Active funded research by the Division of Cardiothoracic Anesthesia faculty include the areas of neurologic outcomes, hemostatic perturbations resulting from cardiac surgery, and critical care related investigations. Other department members are extensively involved in basic research related to anesthesia and pain mechanisms, vascular biology, sepsis, genetics, and other areas. The inter-disciplinary approach at Washington University School of Medicine provides outstanding opportunities for participation in nearly every area of biomedical research. Fellow involvement ranges from participation in active research protocols to mentored development of fellow initiated protocols. The latter avenue provides experience in formulating clear and relevant hypothesis, research protocol design, analysis and data interpretation, and reporting of the results. The aim of this training is to provide the fellow with opportunities to present original research at national meetings and publication of the results in peer-reviewed journal. Continuation of fellowship training is possible for selected individuals to provide further focused research training.