Evan D. Kharasch, MD, PhD to deliver the John W. Severinghaus Lecture on Translational Science
Aug 01, 2014
John W. Severinghaus Lecture on Translational Science: ‘Basic Science to Clinical Practice: The Tale of Long-Acting Opioids’
Evan Kharasch, MD, PhD
This year’s John W. Severinghaus Lecture on Translational Science will be delivered by Evan D. Kharasch, M.D., Ph.D. Dr. Kharasch is the Russell D. and Mary B. Sheldon Professor of Anesthesiology, and Director, Division of Clinical and Translational Research, Department of Anesthesiology, and Professor of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, Missouri.
The lecture will focus on opioids such as methadone that provide long-lasting relief of acute, perioperative, chronic and cancer pain, and which are pivotal to anesthesia practice. With an increase in methadone use, however, there has been a terrifying increase in untoward events. Only recently has there been a better understanding of methadone pharmacology, including pharmacokinetics, pharmacodynamics and pharmacogenetics.
Dr. Kharasch’s lecture tells the story of how these clinical problems were studied in the basic science laboratory, how the insights gained were then verified in clinical trials, and how this new knowledge can guide clinical practice and improve clinical outcome and guide practice.
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