Wayland Cheng MD, PhD has been awarded the IARS Mentored Research Award

Aug 03, 2017

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Wayland Cheng MD, PhD has been awarded the International Anesthesia Research Society (IARS) Mentored Research Award.

Wayland Cheng MD, PhD has been awarded the International Anesthesia Research Society (IARS) Mentored Research Award. This award is a two-year faculty grant intended to support research in the field of anesthesiology and to facilitate the transition to becoming an independent investigator.

Dr. Cheng received the grant from IARS for his project titled “Structural Basis of Neurosteroid Binding to the GABA(A) Receptor”. Neurosteroids are positive allosteric modulators of the GABA(A) receptor and have therapeutic potential as anesthetics and anti-convulsants. The proposed research will use photoaffinity labeling to map neurosteroid binding sites in the GABA(A) receptor. In addition, Dr. Cheng will apply novel mass spectrometry techniques to determine the stoichiometry and modes of neurosteroid binding. This work will define the structural determinants of neurosteroid modulation of the GABA(A) receptor, and may inform the design of neurosteroid-based therapeutics with greater specificity.

Dr. Cheng’s research specializes in the pharmacology of neuronal receptors such as ion channels and G-protein coupled receptors. His long-term interest is to apply mass spectrometry and structural biology techniques to study the molecular basis of anesthetic action, and to characterize the interaction between lipids, which vary significantly in different disease states, and anesthetics in modulating receptors in the brain.

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