2011 Publications

Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin or Bupropion. Drug Metab Dispos. 2011 Dec 21. [Epub ahead of print] PubMed PMID: 22190694.

Sharma A, Tallchief D, Blood J, Kim T, London A, Kharasch ED. Perioperative pharmacokinetics of methadone in adolescents. Anesthesiology. 2011 Dec;115(6):1153-61. PubMed PMID: 22037641. Brown SM, Holtzman M, Kim T, Kharasch ED. Buprenorphine Metabolites, Buprenorphine-3-glucuronide and Norbuprenorphine-3-glucuronide, Are Biologically Active. Anesthesiology. 2011 Dec;115(6):1251-1260. PubMed PMID: 22037640.

Fan J, Meissner K, Gaehle GG, Li S, Kharasch ED, Mach RH, Tu Z. Automated radiosynthesis of [11C]morphine for clinical investigation. Appl Radiat Isot. 2011 Feb;69(2):431-5. Epub 2010 Nov 11. PubMed PMID: 21112214; PubMed Central PMCID: PMC3026438. Kharasch ED. Intraoperative methadone: rediscovery, reappraisal, and reinvigoration? Anesth Analg. 2011 Jan;112(1):13-6. PubMed PMID: 21173206.

Kharasch ED, Vangveravong S, Buck N, London A, Kim T, Blood J, Mach RH. Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. Clin Pharmacol Ther. 2011 Apr;89(4):562-70. Epub 2011 Feb 23. PubMed PMID: 21346758.

Kim T, London A, Kharasch ED. Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry. J Pharm Biomed Anal. 2011 Jun 1;55(3):487-93. Epub 2011 Mar 5. PubMed PMID: 21382685; PubMed Central PMCID: PMC3089954.

Schwedt TJ, Gereau RW, Frey K, Kharasch ED. Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis. Cephalalgia. 2011 Jul;31(10):1082-9. doi: 10.1177/0333102411398155. Epub 2011 Mar 11. PubMed PMID: 21398420.

Kirby BJ, Collier AC, Kharasch ED, Whittington D, Thummel KE, Unadkat JD. Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Drug Metab Dispos. 2011 Jun;39(6):1070-8. Epub 2011 Mar 15. PubMed PMID: 21406602; PubMed Central PMCID: PMC3100903.

Fan J, Brown SM, Tu Z, Kharasch ED. Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide. Bioconjug Chem. 2011 Apr 20;22(4):752-8. Epub 2011 Mar 24. PubMed PMID: 21434652; PubMed Central PMCID: PMC3091394.

Kharasch ED, Francis A, London A, Frey K, Kim T, Blood J. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. Clin Pharmacol Ther. 2011 Jul;90(1):100-8. doi: 10.1038/clpt.2011.59. Epub 2011 May 11. PubMed PMID: 21562488.

Bloom J, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, Goate A, Murphy SE. The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenet Genomics. 2011 Jul;21(7):403-16. doi: 10.1097/FPC.0b013e328346e8c0. PubMed PMID: 21597399; PubMed Central PMCID: PMC3116045.

Nagele P, Tallchief D, Blood J, Sharma A, Kharasch ED. Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesth Analg. 2011 Oct;113(4):843-8. Epub 2011 Jun 16. PubMed PMID: 21680854; PubMed Central PMCID: PMC3183370.

Morrissey JJ, London AN, Lambert MC, Kharasch ED. Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma. Am J Nephrol. 2011;34(5):391-8. Epub 2011 Sep 7. PubMed PMID: 21912102.

Kirby BJ, Collier AC, Kharasch ED, Dixit V, Desai P, Whittington D, Thummel KE, Unadkat JD. Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir. Drug Metab Dispos. 2011 Dec;39(12):2329-37. Epub 2011 Sep 19. PubMed PMID: 21930825; PubMed Central PMCID: PMC3226381.

Aubuchon J, Krucylak C, Murray DJ. Subglottic airway foreign body: a near miss. Anesthesiology. 2011 Dec;115(6):1300. PubMed PMID: 22108306. Fehr JJ, Boulet JR, Waldrop WB, Snider R, Brockel M, Murray DJ. Simulation-based Assessment of Pediatric Anesthesia Skills. Anesthesiology. 2011 Dec;115(6):1308-1315. PubMed PMID: 22037637.

McBride ME, Waldrop WB, Fehr JJ, Boulet JR, Murray DJ. Simulation in pediatrics: the reliability and validity of a multiscenario assessment. Pediatrics. 2011 Aug;128(2):335-43. Epub 2011 Jul 11. PubMed PMID: 21746717. Murray DJ. Current trends in simulation training in anesthesia: a review. Minerva Anestesiol. 2011 May;77(5):528-33. Epub 2011 Feb 1. Review. PubMed PMID: 21540808.

Nagele P. Perioperative genomics. Best Pract Res Clin Anaesthesiol. 2011 Dec;25(4):549-55. PubMed PMID: 22099920; PubMed Central PMCID: PMC3222886. Nagele P, Liggett SB. Genetic Variation, β-blockers, and Perioperative Myocardial Infarction. Anesthesiology. 2011 Dec;115(6):1316-27. PubMed PMID: 21918425; PubMed Central PMCID: PMC3226841.

Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ, Hill SA, Thomas S, Mrkobrada M, Alonso-Coello P, Berwanger O, Biccard BM, Cembrowski G, Chan MT, Chow CK, de Miguel A, Garcia M, Graham MM, Jacka MJ, Kueh JH, Li SC, Lit LC, Martínez-Brú C, Naidoo P, Nagele P, Pearse RM, Rodseth RN, Sessler DI, Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier D, Devereaux PJ. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study. Clin Biochem. 2011 Aug;44(12):1021-4. Epub 2011 May 24. PubMed PMID: 21640092.

Nagele P, Meissner K, Francis A, Födinger M, Saccone NL. Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. Pharmacogenet Genomics. 2011 Jul;21(7):426-31. doi: 10.1097/FPC.0b013e32834741ff. PubMed PMID: 21597397; PubMed Central PMCID: PMC3116052.

Nagele P. Augmented CPR: rescue after the ResQ trial. Lancet. 2011 Jan 22;377(9762):276-8. PubMed PMID: 21251706.

Vannucci A, Johnston J, Earl TM, Doyle M, Kangrga IM. Intraoperative transesophageal echocardiography guides liver transplant surgery in a patient with thrombosed transjugular intrahepatic portosystemic shunt. Anesthesiology. 2011 Dec;115(6):1389-91. PubMed PMID: 22108313.

Tivener D, Vannucci A, Fagley RE, Doyle M, Shenoy S, Chapman W, Kangrga I. Atrial laceration caused by removal of a transjugular intrahepatic portosystemic shunt necessitates emergent cardiopulmonary bypass during liver transplant: a case report. Transplant Proc. 2011 Sep;43(7):2810-3. PubMed PMID: 21911169.

Vannucci A, Tran LC, Kangrga IM. Inflammatory Myofibroblastic Tumor within Intrahepatic Inferior Vena Cava. Anesthesiology. 2011 Dec;115(6):1299. PubMed PMID: 21785338.

Whitlock EL, Villafranca AJ, Lin N, Palanca BJ, Jacobsohn E, Finkel KJ, Zhang L, Burnside BA, Kaiser HA, Evers AS, Avidan MS. Relationship between Bispectral Index Values and Volatile Anesthetic Concentrations during the Maintenance Phase of Anesthesia in the B-Unaware Trial. Anesthesiology. 2011 Dec;115(6):1209-1218. PubMed PMID: 22037642.

Graetz TJ, Tellor BR, Smith JR, Avidan MS. Desirudin: a review of the pharmacology and clinical application for the prevention of deep vein thrombosis. Expert Rev Cardiovasc Ther. 2011 Sep;9(9):1101-9. PubMed PMID: 21932952.

Avidan MS, Jacobsohn E, Glick D, Burnside BA, Zhang L, Villafranca A, Karl L, Kamal S, Torres B, O'Connor M, Evers AS, Gradwohl S, Lin N, Palanca BJ, Mashour GA; BAG-RECALL Research Group. Prevention of intraoperative awareness in a high-risk surgical population. N Engl J Med. 2011 Aug 18;365(7):591-600. PubMed PMID: 21848460.

Avidan MS, Smith JR, Skrupky LP, Hill L, Jacobsohn E, Burnside B, Tymkew H, Eby C, Damiano R, Despotis GJ. The occurrence of antibodies to heparin-platelet factor 4 in cardiac and thoracic surgical patients receiving desirudin or heparin for postoperative venous thrombosis prophylaxis. Thromb Res. 2011 Dec;128(6):524-9. Epub 2011 Jul 26. PubMed PMID: 21794899.

Mashour GA, Avidan MS. Pharmacologic approaches to the prevention of intraoperative awareness. Expert Rev Neurother. 2011 May;11(5):611-3. PubMed PMID: 21539481.

Whitlock EL, Vannucci A, Avidan MS. Postoperative delirium. Minerva Anestesiol. 2011 Apr;77(4):448-56. Review. PubMed PMID: 21483389. Mashour GA, Orser BA, Avidan MS. Intraoperative awareness: from neurobiology to clinical practice. Anesthesiology. 2011 May;114(5):1218-33. Review. PubMed PMID: 21464699.

Bottros MM, Palanca BJ, Mashour GA, Patel A, Butler C, Taylor A, Lin N, Avidan MS. Estimation of the bispectral index by anesthesiologists: an inverse turing test. Anesthesiology. 2011 May;114(5):1093-101. PubMed PMID: 21460704. Avidan MS, Evers AS. Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia. J Alzheimers Dis. 2011;24(2):201-16. Review. PubMed PMID: 21447878.

Kertai MD, Palanca BJ, Pal N, Burnside BA, Zhang L, Sadiq F, Finkel KJ, Avidan MS; B-Unaware Study Group. Bispectral index monitoring, duration of bispectral index below 45, patient risk factors, and intermediate-term mortality after noncardiac surgery in the B-Unaware Trial. Anesthesiology. 2011 Mar;114(3):545-56. PubMed PMID: 21293252.